BD-PM3164

eNOS(Mix)Mouse Monoclonal Antibody

NOS3; Nitric oxide synthase, endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII

常规抗体

NOS3

Nitric oxide synthase, endothelial

WB

Human,Mouse,Rat,Rabbit

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

4846

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4846

P29474

http://www.uniprot.org/uniprotkb/P29474/entry

18127

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18127

P70313

http://www.uniprot.org/uniprot/P70313

24600

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24600

Q62600

http://www.uniprot.org/uniprot/Q62600

Recombinant Protein of eNOS

The antibody detects endogenous eNOS protein.

WB 1:500-2000

130-140kD

-20°C/1 year

Monoclonal, Mouse

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],

Platelets, placenta, liver and kidney.

Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.

Arginine and proline metabolism;Calcium;VEGF;

catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.,function:Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.,online information:Nitric oxide synthase entry,polymorphism:Variation in NOS3 seem to be associated with susceptibility to coronary spasm.,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subcellular location:Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.,subunit:Homodimer. Interacts with NOSIP and NOSTRIN.,tissue specificity:Platelets, placenta, liver and kidney.,

现货

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.