产品名称
Neuropilin-2 Rabbit Polyclonal Antibody
别名
NRP2; VEGF165R2; Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8828
Human Swissprot No.
O60462
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60462/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18187
Mouse Swissprot No.
O35375
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35375
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81527
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35276
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NRP2. AA range:791-840
特异性
Neuropilin-2 Polyclonal Antibody detects endogenous levels of Neuropilin-2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
组织表达
Brain,Human endometrium carcinoma cell line,Liver,Mammary gland,Ovary,Prostate adenocarcino
细胞定位
Membrane ; Single-pass type I membrane protein .; [Isoform s9]: Secreted .
功能
function:High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.,similarity:Belongs to the neuropilin family.,similarity:Contains 1 MAM domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 F5/8 type C domains.,subunit:Heterodimer with NRP1 (Probable). Binds PLXNB1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
