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Neuregulin-2 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5215
产品名称
Neuregulin-2 Rabbit Polyclonal Antibody
别名
NRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
类别
常规抗体
基因名称
NRG2
蛋白名称
Pro-neuregulin-2 membrane-bound isoform
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
9542
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9542
Human Swissprot No.
O14511
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14511/entry
Mouse Swissprot No.
P56974
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56974
Rat Gene ID
432361
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432361
Rat Swissprot No.
O35569
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35569
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NRG2. AA range:361-410
特异性
Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
90kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010],
组织表达
Restricted to the cerebellum in the adult.
细胞定位
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-2]: Secreted .
信号通路
ErbB_HER;
功能
domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subcellular location:Does not seem to be active.,tissue specificity:Restricted to the cerebellum in the adult.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from HT29 cells, using NRG2 Antibody.

Western Blot analysis of HT29 cells using Neuregulin-2 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100

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