BD-PT5213-FOXP1 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

FOXP1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT5213

产品名称

FOXP1 Rabbit Polyclonal Antibody

别名

FOXP1; HSPC215; Forkhead box protein P1

类别

常规抗体

基因名称

FOXP1

蛋白名称

Forkhead box protein P1

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

27086

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27086

Human Swissprot No.

Q9H334

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q9H334/entry

Mouse Gene ID

108655

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108655

Mouse Swissprot No.

P58462

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P58462

Rat Gene ID

297480

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=297480

Rat Swissprot No.

Q498D1

Rat Swissprot Link

http://www.uniprot.org/uniprot/Q498D1

免疫原

The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP1. AA range:628-677

特异性

FOXP1 Polyclonal Antibody detects endogenous levels of FOXP1 protein.

稀释度

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200

预测分子量

75kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

组织表达

Isoform 8 is specifically expressed in embryonic stem cells.

细胞定位

Nucleus . Not found in the nucleolus. .

功能

alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.,domain:The leucine-zipper is required for dimerization and transcriptional repression.,function:Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of K562 cells using FOXP1 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Western Blot analysis of customer‘s using FOXP1 Antibody Polyclonal Antibody.

Immunohistochemical analysis of paraffin-embedded mouse-lung, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded Human lymphoma. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.