BD-PT5212

Fascin 1 Rabbit Polyclonal Antibody

FSCN1; FAN1; HSN; SNL; Fascin; 55 kDa actin-bundling protein; Singed-like protein; p55

常规抗体

FSCN1

Fascin

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6624

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6624

Q16658

http://www.uniprot.org/uniprotkb/Q16658/entry

14086

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14086

Q61553

http://www.uniprot.org/uniprot/Q61553

683788

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=683788

P85845

http://www.uniprot.org/uniprot/P85845

The antiserum was produced against synthesized peptide derived from the Internal region of human FSCN1. AA range:261-310

Fascin 1 Polyclonal Antibody detects endogenous levels of Fascin 1 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200

55kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011],

Ubiquitous.

Cytoplasm, cytosol . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Cell projection, filopodium . Cell projection, invadopodium . Cell projection, microvillus . Cell junction . Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). .

disease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001). Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival, but not bone metastasis-free survival, compared to subjects without the signature.,function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.,similarity:Belongs to the fascin family.,subunit:Associates with beta-catenin.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.