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CD68 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5210
产品名称
CD68 Rabbit Polyclonal Antibody
别名
CD68; Macrosialin; Gp110; CD68
类别
常规抗体
基因名称
CD68
蛋白名称
Macrosialin
推荐应用
WB
反应种属
Human,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
968
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=968
Human Swissprot No.
P34810
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P34810/entry
Mouse Swissprot No.
P31996
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P31996
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CD68. AA range:171-220
特异性
CD68 Polyclonal Antibody detects endogenous levels of CD68 protein.
稀释度
WB 1:500 - 1:2000.
预测分子量
37kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
细胞定位
[Isoform Short]: Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
信号通路
Lysosome;
功能
function:Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.,PTM:N- and O-glycosylated.,similarity:Belongs to the LAMP family.,tissue specificity:Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from mouse spleen cells, using CD68 Antibody.

Western Blot analysis of mouse spleen cells using CD68 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

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