产品名称
Calbindin D28K Rabbit Polyclonal Antibody
别名
CALB1; CAB27; Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=793
Human Swissprot No.
P05937
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P05937/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12307
Mouse Swissprot No.
P12658
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P12658
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83839
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07171
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CALB1. AA range:191-240
特异性
Calbindin D28K Polyclonal Antibody detects endogenous levels of Calbindin D28K protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015],
组织表达
Brain,Cerebellum,Kidney,Lung,Substantia nigra,
细胞定位
nucleus,cytosol,axon,dendrite,neuronal cell body,terminal bouton,synapse,extracellular exosome,
功能
domain:This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.,function:Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 5 EF-hand domains.,subunit:Interacts with RANBP9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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