BD-PT5208-BLC Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

BLC Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT5208

产品名称

BLC Rabbit Polyclonal Antibody

别名

CXCL13; BCA1; BLC; SCYB13; C-X-C motif chemokine 13; Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13

类别

常规抗体

基因名称

CXCL13

蛋白名称

C-X-C motif chemokine 13

推荐应用

反应种属

Human,Rat,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

10563

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10563

Human Swissprot No.

O43927

Human Swissprot Link

http://www.uniprot.org/uniprotkb/O43927/entry

Mouse Swissprot No.

O55038

Mouse Swissprot Link

http://www.uniprot.org/uniprot/O55038

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human CXCL13. AA range:41-90

特异性

BLC Polyclonal Antibody detects endogenous levels of BLC protein.

稀释度

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200

预测分子量

15kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

C-X-C motif chemokine ligand 13(CXCL13) Homo sapiens B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014],

组织表达

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

细胞定位

Secreted.

信号通路

Cytokine-cytokine receptor interaction;Chemokine;

功能

function:Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.,online information:CXCL13 entry,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,tissue specificity:Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from mouse spleen cells, using CXCL13 Antibody.

Western Blot analysis of mouse spleen cells using BLC Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-muscle, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded Human Liver. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.