Cn|En

现货抗体产品库

CEACAM1/5 Rabbit Polyclonal Antibody

产品详情 相关文献 产品问答 相关产品

产品基本信息

产品货号
BD-PT5205
产品名称
CEACAM1/5 Rabbit Polyclonal Antibody
别名
CEACAM1; BGP; BGP1; Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1; BGP-1; CD66a; CEACAM5; CEA; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e
类别
常规抗体
基因名称
CEACAM1/CEACAM5
蛋白名称
Carcinoembryonic antigen-related cell adhesion molecule 1/Carcinoembryonic antigen-related cell adhesion molecule 5
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
634
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=634
Human Swissprot No.
P13688
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13688/entry
Mouse Swissprot No.
P31809
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P31809
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CEACAM1/CEACAM5. AA range:31-80
特异性
CEACAM1/5 Polyclonal Antibody detects endogenous levels of CEACAM1/5 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
58kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue thre
组织表达
Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Lateral cell membrane . Apical cell membrane . Basal cell membrane . Cell junction . Cell junction, adherens junction . Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 6]: Cell membrane; Single-pass type I membrane protein.; [Isoform 7]: Cell membrane; Single-pass type I membrane protein.; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle membrane . Lateral cell membrane . Apical cell membrane . Basal cell membrane . Cell junction . Cell junction, adherens junction . Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). .; Cell projection, microvillus membrane ; Single-pass type I membrane protein . Apical cell membrane ; Single-pass type I membrane protein . Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells. .
功能
disease:Increased serum levels of BGP-1 are found in individuals suffering from hepatic disorders.,disease:Loss or reduced expression is a major event in colorectal carcinogenesis.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of HepG2 cells using CEACAM1/5 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

相关文献

产品问答

相关产品

免责声明| 法律支持| 联系方式

市场:027-65023363   行政/人事:027-62439686   邮箱:marketing@brainvta.com  

销售总监:张经理  18995532642  华东区:陈经理 18013970337   华南区:王经理 13100653525   华中/西区:杨经理 18186518905   华北区:张经理 18893721749

地址:中国武汉东湖高新区光谷七路128号中科开物产业园1号楼

Copyright © 武汉枢密脑科学技术有限公司. All RIGHTS RESERVED.
鄂ICP备2021009124号 DIGITAL BY VTHINK