产品名称
CyPA Rabbit Polyclonal Antibody
别名
PPIA; CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A
蛋白名称
Peptidyl-prolyl cis-trans isomerase A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5478
Human Swissprot No.
P62937
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P62937/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268373
Mouse Swissprot No.
P17742
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P17742
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100360977
Rat Swissprot Link
http://www.uniprot.org/uniprot/P10111
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PPIA. AA range:51-100
特异性
CyPA Polyclonal Antibody detects endogenous levels of CyPA protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008],
组织表达
Blood,Bone marrow,Brain,Cajal-Retzius cell,Cervix,Colon,Epithelium,Fetal br
细胞定位
Cytoplasm . Secreted . Nucleus . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. .
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subunit:Interacts with HIV-1 Capsid protein.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
.jpg)
.jpg)
