产品名称
EST1 Rabbit Polyclonal Antibody
别名
Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.142% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1066
Human Swissprot No.
P23141
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23141/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12623
Mouse Swissprot No.
Q8VCC2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCC2
免疫原
Synthesized peptide derived from human EST1 AA range: 7-57
特异性
This antibody detects endogenous levels of EST1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
组织表达
Expressed predominantly in liver with lower levels in heart and lung (PubMed:10562416). Expressed in macrophages (PubMed:11015575, PubMed:21049984, PubMed:18762277).
细胞定位
Endoplasmic reticulum lumen . Cytoplasm . Lipid droplet . Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. .
功能
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,enzyme regulation:Activated by CHAPS.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester.,PTM:Contains sialic acid.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotrimer and homohexamer. Binds to beta-glucuronidase.,tissue specificity:Expressed predominantly in liver with lower levels in heart and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
