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SP-A Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5191
产品名称
SP-A Rabbit Polyclonal Antibody
别名
SFTPA2; COLEC5; PSAP; SFTP1; SFTPA; SFTPA2B; Pulmonary surfactant-associated protein A2; PSP-A; PSPA; SP-A; SP-A2; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-5; SFTPA1; COLEC4; PSAP;SFTP1; SFTPA; SFTPA1B; Pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4
类别
常规抗体
基因名称
SFTPA2/SFTPA1
蛋白名称
Pulmonary surfactant-associated protein A2/Pulmonary surfactant-associated protein A1
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
729238
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=729238
Human Swissprot No.
Q8IWL1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IWL1/entry
Rat Gene ID
24773
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24773
Rat Swissprot No.
P08427
Rat Swissprot Link
http://www.uniprot.org/uniprot/P08427
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human SFTPA1/2. AA range:141-190
特异性
SP-A Polyclonal Antibody detects endogenous levels of SP-A protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
34kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009],
细胞定位
Secreted . Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
功能
function:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,polymorphism:At least 6 alleles of SFTPA2 are known: 1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown is that of allele 1A(0).,similarity:Belongs to the SFTPA family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from K562 cells, using SFTPA1/2 Antibody.

Western Blot analysis of K562, mouse lung cells using SP-A Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:100

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