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CUL-4B Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5188
产品名称
CUL-4B Rabbit Polyclonal Antibody
别名
CUL4B; KIAA0695; Cullin-4B; CUL-4B
类别
常规抗体
基因名称
CUL4B
蛋白名称
Cullin-4B
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
8450
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8450
Human Swissprot No.
Q13620
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13620/entry
Mouse Gene ID
72584
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72584
Mouse Swissprot No.
A2A432
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2A432
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CUL4B. AA range:711-760
特异性
CUL-4B Polyclonal Antibody detects endogenous levels of CUL-4B protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
110kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Brain,Fetal liver,Testis,
细胞定位
Nucleus .
信号通路
Nucleotide excision repair;Ubiquitin mediated proteolysis;
功能
disease:Defects in CUL4B are the cause of Cabezas X-linked mental retardation syndrome (MRXC) [MIM:300354]; also called X-linked mental retardation with short stature small testes muscle wasting and tremor. MRXC patients show delayed puberty, hypogonadism, relative macrocephaly, moderate short stature, central obesity, unprovoked aggressive outbursts, fine intention tremor, pes cavus, and abnormalities of the toes.,disease:Defects in CUL4B are the cause of X-linked mental retardation-hypotonic facies syndrome type 2 (MRXHF2) [MIM:300639]; also called Smith-Fineman-Myers syndrome type 2 or SFM2. The distinguishing manifestations of MRXHF2 are relative microcephaly, short stature, hypertelorism, macrostomia, patulous lips, difficulty in speech, micrognathia, short thumbs and little fingers with adduction, hypotonia at age less than 10 years, and later hypertonia, restlessness, and seizures. IQ ranged from 40 to 57. Obligate carrier females were clinically normal except for rather large hands with deep palmar and finger creases with rhagades.,function:Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. DC4BX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 in response to radiation-induced DNA damage and during DNA replication. Required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair.,pathway:Protein modification; protein ubiquitination.,PTM:Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.,similarity:Belongs to the cullin family.,subunit:Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and TIP120A/CAND1. Interacts with RBX1 and TIP120A/CAND1. Interacts with TMEM113. Interacts with GRWD1, SMU1, TLE2, TLE3, VPRBP, DDA1, IQWD1, C2orf37, DDB2, WDR23, WDR42A. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from mouse liver cells, using CUL4B Antibody.

Western Blot analysis of mouse liver, mouse kidney, mouse heart cells using CUL-4B Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

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