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PARP(M3)Mouse Monoclonal Antibody

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产品基本信息

产品货号
BD-PM3131
产品名称
PARP(M3)Mouse Monoclonal Antibody
别名
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)
类别
常规抗体
基因名称
PARP1
蛋白名称
Poly [ADP-ribose] polymerase 1
推荐应用
WB
反应种属
Human,Chicken(testedbyourcustomer)
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene ID
142
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142
Human Swissprot No.
P09874
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09874/entry
Mouse Swissprot No.
P11103
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P11103
Rat Gene ID
25591
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25591
Rat Swissprot No.
P27008
Rat Swissprot Link
http://www.uniprot.org/uniprot/P27008
免疫原
Synthetic Peptide of PARP
特异性
The antibody detects endogenous PARP protein.
稀释度
WB 1:1000-3000
预测分子量
116kD
运输及保存条件
-20°C/1 year
宿主
Monoclonal, Mouse
背景介绍
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],
组织表达
Brain,Colon carcinoma,Fibroblast,Lung,Ovarian carcinoma,Skin,
细胞定位
Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
信号通路
Base excision repair;
功能
catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
期货
现货
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Western blot analysis of 1) Hela, 2) 293T, 3) Jurkat, diluted at 1:2000. cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

Western Blot analysis of chicken cell lysis using Antibody diluted at 1:1000

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