BD-PT5180

Lamin B1 Rabbit Polyclonal Antibody

LMNB1; LMN2; LMNB; Lamin-B1

常规抗体

LMNB1

Lamin-B1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4001

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4001

P20700

http://www.uniprot.org/uniprotkb/P20700/entry

16906

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16906

P14733

http://www.uniprot.org/uniprot/P14733

116685

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116685

P70615

http://www.uniprot.org/uniprot/P70615

The antiserum was produced against synthesized peptide derived from the Internal region of human LMNB1. AA range:391-440

Lamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200

70kD

-20°C/1 year

Polyclonal, Rabbit,IgG

lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,

Nucleus lamina .

disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with lamin-associated polypeptides IA, IB and 2.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.