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Lamin B1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5180
产品名称
Lamin B1 Rabbit Polyclonal Antibody
别名
LMNB1; LMN2; LMNB; Lamin-B1
类别
常规抗体
基因名称
LMNB1
蛋白名称
Lamin-B1
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
4001
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4001
Human Swissprot No.
P20700
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20700/entry
Mouse Gene ID
16906
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16906
Mouse Swissprot No.
P14733
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P14733
Rat Gene ID
116685
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116685
Rat Swissprot No.
P70615
Rat Swissprot Link
http://www.uniprot.org/uniprot/P70615
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human LMNB1. AA range:391-440
特异性
Lamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
70kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,
细胞定位
Nucleus lamina .
功能
disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with lamin-associated polypeptides IA, IB and 2.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from MCF7 cells, using LMNB1 Antibody.

Western Blot analysis of MCF7, SW480, PC-3, SKOV3, mouse spleen, mouse brain, mouse liver, mouse thymus cells using Lamin B1 Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

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