产品名称
FGF-20 Rabbit Polyclonal Antibody
别名
FGF20; Fibroblast growth factor 20; FGF-20
蛋白名称
Fibroblast growth factor 20
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26281
Human Swissprot No.
Q9NP95
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NP95/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80857
Mouse Swissprot No.
Q9ESL9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ESL9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66017
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9EST9
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human FGF20. AA range:151-200
特异性
FGF-20 Polyclonal Antibody detects endogenous levels of FGF-20 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009],
组织表达
Predominantly expressed in the cerebellum.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能
function:Neurotrophic factor that regulates central nervous development and function.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Predominantly expressed in the cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.