产品名称
LMF1 Rabbit Polyclonal Antibody
别名
Lipase maturation factor 1 (Transmembrane protein 112)
基因名称
LMF1 C16orf26 TMEM112 HMFN1876 JFP11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.144% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64788
Human Swissprot No.
Q96S06
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96S06/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/76483
Mouse Swissprot No.
Q3U3R4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U3R4
免疫原
Synthesized peptide derived from human LMF1 AA range: 257-307
特异性
This antibody detects endogenous levels of LMF1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene resides in the endoplasmic reticulum, and is involved in the maturation and transport of lipoprotein lipase through the secretory pathway. Mutations in this gene are associated with combined lipase deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010],
组织表达
Hepatoblastoma,Kidney epithelium,Pancreas,Teratocarcinoma,Testis,
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
disease:Defects in LMF1 are the cause of combined lipase deficiency (CLD) [MIM:246650]. CLD is characterized by repeated episodes of pancreatitis, tuberous xanthomas and lipodystrophy and is caused by deficiency of both lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL).,function:Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway.,similarity:Belongs to the lipase maturation factor family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
