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IL-16 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5175
产品名称
IL-16 Rabbit Polyclonal Antibody
别名
IL16; Pro-interleukin-16
类别
常规抗体
基因名称
IL16
蛋白名称
Pro-interleukin-16
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
3603
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3603
Human Swissprot No.
Q14005
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14005/entry
Mouse Swissprot No.
O54824
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54824
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL16. AA range:1281-1330
特异性
IL-16 Polyclonal Antibody detects endogenous levels of IL-16 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
140kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
组织表达
[Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.
细胞定位
[Interleukin-16]: Secreted.; [Isoform 1]: Cytoplasm .; [Isoform 3]: Cytoplasm. Nucleus.
功能
function:Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.,function:Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.,function:Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.,induction:Isoform 3 is down-regulated in T-cells after TCR activation.,PTM:Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 2 PDZ (DHR) domains.,similarity:Contains 4 PDZ (DHR) domains.,subunit:Homotetramer (Probable); according (PubMed:9699630) the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax.,tissue specificity:Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from 293 cells, using IL16 Antibody.

Western Blot analysis of 293, HepG2, BXPC-3, Raji, mouse lung, mouse brain, mouse spleen cells using IL-16 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100

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