产品名称
PGM5 Rabbit Polyclonal Antibody
别名
Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.145% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5239
Human Swissprot No.
Q15124
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15124/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/226041
Mouse Swissprot No.
Q8BZF8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZF8
免疫原
Synthesized peptide derived from human PGM5 AA range: 357-407
特异性
This antibody detects endogenous levels of PGM5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008],
组织表达
Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).
细胞定位
Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell membrane, sarcolemma . Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. .
功能
cofactor:Binds 1 magnesium ion per subunit .,function:Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.,similarity:Belongs to the phosphohexose mutase family.,subcellular location:Adherens-type cellular junctions.,subunit:Interacts with cytoskeletal proteins dystrophin and utrophin.,tissue specificity:Expressed in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
