产品名称
CPE Rabbit Polyclonal Antibody
别名
CPE; Carboxypeptidase E; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1363
Human Swissprot No.
P16870
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P16870/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12876
Mouse Swissprot No.
Q00493
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q00493
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25669
Rat Swissprot Link
http://www.uniprot.org/uniprot/P15087
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CPE. AA range:427-476
特异性
CPE Polyclonal Antibody detects endogenous levels of CPE protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
carboxypeptidase E(CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015],
细胞定位
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Secreted . Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. .
信号通路
Type I diabetes mellitus;
功能
catalytic activity:Release of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,function:Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.,similarity:Belongs to the peptidase M14 family.,subcellular location:Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
