BD-PM3112

Peroxiredoxin 1(8E7)Mouse Monoclonal Antibody

PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2

常规抗体

PRDX1

Peroxiredoxin-1

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

5052

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5052

Q06830

http://www.uniprot.org/uniprotkb/Q06830/entry

18477

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18477

P35700

http://www.uniprot.org/uniprot/P35700

117254

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117254

Q63716

http://www.uniprot.org/uniprot/Q63716

Recombinant Protein of Peroxiredoxin-1

The antibody detects endogenous Peroxiredoxin 1 protein.

WB 1:1000-3000 IF 1:100-200 IHC 1:50-300

21kD

-20°C/1 year

Monoclonal, Mouse

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011],

Brain,Cajal-Retzius cell,Fetal brain cortex,Urinary bladder,

Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,function:Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).,induction:Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.,miscellaneous:Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.,miscellaneous:The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,PTM:Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.,similarity:Belongs to the ahpC/TSA family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2.,

现货

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.