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Trk C Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5165
产品名称
Trk C Rabbit Polyclonal Antibody
别名
NTRK3; TRKC; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase
类别
常规抗体
基因名称
NTRK3
蛋白名称
NT-3 growth factor receptor
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
4916
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4916
Human Swissprot No.
Q16288
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16288/entry
Mouse Swissprot No.
Q6VNS1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6VNS1
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NTRK3. AA range:281-330
特异性
Trk C Polyclonal Antibody detects endogenous levels of Trk C protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
预测分子量
95kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
组织表达
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Neurotrophin;
功能
alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from HeLa cells, using NTRK3 Antibody.

Western Blot analysis of HeLa cells using Trk C Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

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