产品名称
Apelin Rabbit Polyclonal Antibody
别名
APLN; APEL; Apelin; APJ endogenous ligand
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8862
Human Swissprot No.
Q9ULZ1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9ULZ1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30878
Mouse Swissprot No.
Q9R0R4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0R4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58812
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9R0R3
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human APLN. AA range:28-77
特异性
Apelin Polyclonal Antibody detects endogenous levels of Apelin protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016],
组织表达
Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103). Secreted by the mammary gland into the colostrum and the milk.
细胞定位
Secreted . Secreted, extracellular space . Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. .
功能
function:Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.,PTM:Several active peptides may be produced by proteolytic processing of the peptide precursor.,similarity:Belongs to the apelin family.,tissue specificity:Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.