BD-PT5163

Apelin Rabbit Polyclonal Antibody

APLN; APEL; Apelin; APJ endogenous ligand

常规抗体

APLN

Apelin

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

8862

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8862

Q9ULZ1

http://www.uniprot.org/uniprotkb/Q9ULZ1/entry

30878

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30878

Q9R0R4

http://www.uniprot.org/uniprot/Q9R0R4

58812

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58812

Q9R0R3

http://www.uniprot.org/uniprot/Q9R0R3

The antiserum was produced against synthesized peptide derived from the C-terminal region of human APLN. AA range:28-77

Apelin Polyclonal Antibody detects endogenous levels of Apelin protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

16kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016],

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103). Secreted by the mammary gland into the colostrum and the milk.

Secreted . Secreted, extracellular space . Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. .

function:Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.,PTM:Several active peptides may be produced by proteolytic processing of the peptide precursor.,similarity:Belongs to the apelin family.,tissue specificity:Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.