产品名称
FGF-12 Rabbit Polyclonal Antibody
别名
FGF12; FGF12B; FHF1; Fibroblast growth factor 12; FGF-12; Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor
蛋白名称
Fibroblast growth factor 12
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2257
Human Swissprot No.
P61328
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P61328/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14167
Mouse Swissprot No.
P61329
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P61329
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170630
Rat Swissprot Link
http://www.uniprot.org/uniprot/P61150
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human FGF12. AA range:31-80
特异性
FGF-12 Polyclonal Antibody detects endogenous levels of FGF-12 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能
function:Probably involved in nervous system development and function.,similarity:Belongs to the heparin-binding growth factors family.,subunit:Interacts with the C-terminal region of SCN9A.,tissue specificity:Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.