产品名称
TFPI-2 Rabbit Polyclonal Antibody
别名
TFPI2; Tissue factor pathway inhibitor 2; TFPI-2; Placental protein 5; PP5
蛋白名称
Tissue factor pathway inhibitor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7980
Human Swissprot No.
P48307
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48307/entry
Mouse Swissprot No.
O35536
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35536
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI2. AA range:186-235
特异性
TFPI-2 Polyclonal Antibody detects endogenous levels of TFPI-2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
组织表达
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
功能
domain:This inhibitor contains three inhibitory domains.,function:May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
