产品名称
RANB3 Rabbit Polyclonal Antibody
别名
Ran-binding protein 3 (RanBP3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.147% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8498
Human Swissprot No.
Q9H6Z4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6Z4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71810
Mouse Swissprot No.
Q9CT10
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CT10
免疫原
Synthesized peptide derived from human RANB3 AA range: 421-471
特异性
This antibody detects endogenous levels of RANB3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with high levels in testis and heart.
细胞定位
Cytoplasm . Nucleus .
功能
function:Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBD1 domain.,subunit:Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1.,tissue specificity:Widely expressed with high levels in testis and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
