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ALDH1A1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5157
产品名称
ALDH1A1 Rabbit Polyclonal Antibody
别名
ALDH1A1; ALDC; ALDH1; PUMB1; Retinal dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic
类别
常规抗体
基因名称
ALDH1A1
蛋白名称
Retinal dehydrogenase 1
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
216
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216
Human Swissprot No.
P00352
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P00352/entry
Mouse Swissprot No.
P24549
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P24549
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDH1A1. AA range:21-70
特异性
ALDH1A1 Polyclonal Antibody detects endogenous levels of ALDH1A1 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
55kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011],
组织表达
Expressed by erythrocytes (at protein level).
细胞定位
Cytoplasm, cytosol . Cell projection, axon .
信号通路
Retinol metabolism;
功能
catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,function:Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from mouse lung, using ALDH1A1 Antibody.

Western Blot analysis of mouse lung, mouse liver cells using ALDH1A1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100

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