产品名称
BNIP-3 Rabbit Polyclonal Antibody
别名
BNIP3; NIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
蛋白名称
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=664
Human Swissprot No.
Q12983
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q12983/entry
Mouse Swissprot No.
O55003
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55003
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human BNIP3. AA range:71-120
特异性
BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014],
组织表达
B-cell,Brain,Cerebellum,Kidney,Testis,
细胞定位
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
功能
function:Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.,similarity:Belongs to the NIP3 family.,subcellular location:Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.,subunit:Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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