产品名称
Cyclophilin D Rabbit Polyclonal Antibody
别名
PPID; CYP40; CYPD; Peptidyl-prolyl cis-trans isomerase D; PPIase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D
蛋白名称
Peptidyl-prolyl cis-trans isomerase D
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5481
Human Swissprot No.
Q08752
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q08752/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67738
Mouse Swissprot No.
Q9CR16
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CR16
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361967
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6DGG0
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPID. AA range:321-370
特异性
Cyclophilin D Polyclonal Antibody detects endogenous levels of Cyclophilin D protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm .
信号通路
Calcium;Parkinson's disease;Huntington's disease;
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Less sensitive to inhibition by cyclosporin A than is CYP-18.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,similarity:Contains 3 TPR repeats.,subunit:Binds ESR1.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
