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AFP Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5140
产品名称
AFP Rabbit Polyclonal Antibody
别名
AFP; HPAFP; Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin
类别
常规抗体
基因名称
AFP
蛋白名称
Alpha-fetoprotein
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
174
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=174
Human Swissprot No.
P02771
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P02771/entry
Mouse Swissprot No.
P02772
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P02772
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human AFP. AA range:371-420
特异性
AFP Polyclonal Antibody detects endogenous levels of AFP protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
70kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008],
组织表达
Plasma. Synthesized by the fetal liver and yolk sac.
细胞定位
Secreted.
功能
developmental stage:Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.,function:Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.,online information:Alpha-fetoprotein entry,PTM:Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.,PTM:Sulfated.,similarity:Belongs to the ALB/AFP/VDB family.,similarity:Contains 3 albumin domains.,subunit:Dimeric and trimeric forms have been found in addition to the monomeric form.,tissue specificity:Plasma. Synthesized by the fetal liver and yolk sac.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from mouse liver cells, using AFP Antibody.

Western Blot analysis of mouse liver, mouse serum cells using AFP Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100

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