产品名称
Claudin-17 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26285
Human Swissprot No.
P56750
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P56750/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=239931
Mouse Swissprot No.
Q8BXA6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BXA6
免疫原
Synthesized peptide derived from Claudin-17 . at AA range: 150-230
特异性
Claudin-17 Polyclonal Antibody detects endogenous levels of Claudin-17 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010],
组织表达
In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.