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Claudin-17 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5136
产品名称
Claudin-17 Rabbit Polyclonal Antibody
别名
CLDN17; Claudin-17
类别
常规抗体
基因名称
CLDN17
蛋白名称
Claudin-17
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
26285
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26285
Human Swissprot No.
P56750
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P56750/entry
Mouse Gene ID
239931
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=239931
Mouse Swissprot No.
Q8BXA6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BXA6
免疫原
Synthesized peptide derived from Claudin-17 . at AA range: 150-230
特异性
Claudin-17 Polyclonal Antibody detects endogenous levels of Claudin-17 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
预测分子量
24kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010],
组织表达
In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of Raji, BT474, K562, mouse heart, mouse skeletal muscle cells using Claudin-17 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

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