产品名称
Chymase Rabbit Polyclonal Antibody
别名
CMA1; CYH; CYM; Chymase; Alpha-chymase; Mast cell protease I
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1215
Human Swissprot No.
P23946
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23946/entry
Mouse Swissprot No.
P21844
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P21844
免疫原
Synthesized peptide derived from the Internal region of human Chymase.
特异性
Chymase Polyclonal Antibody detects endogenous levels of Chymase protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
chymase 1(CMA1) Homo sapiens This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015],
组织表达
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
细胞定位
Secreted. Cytoplasmic granule. Mast cell granules.
信号通路
Renin-angiotensin system;
功能
catalytic activity:Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.,function:Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Mast cell granules.,tissue specificity:Mast cells in lung, heart, skin and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
