BD-PT5122

Contactin 1 Rabbit Polyclonal Antibody

CNTN1; Contactin-1; Glycoprotein gp135; Neural cell surface protein F3

常规抗体

CNTN1

Contactin-1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1272

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1272

Q12860

http://www.uniprot.org/uniprotkb/Q12860/entry

12805

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12805

P12960

http://www.uniprot.org/uniprot/P12960

117258

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117258

Q63198

http://www.uniprot.org/uniprot/Q63198

Synthesized peptide derived from the N-terminal region of human Contactin 1.

Contactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

113kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Cell adhesion molecules (CAMs);

disease:Defects in CNTN1 are the cause of Compton-North congenital myopathy [MIM:612540]. Compton-North congenital myopathy is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.,function:Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.,similarity:Belongs to the immunoglobulin superfamily. Contactin family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.,tissue specificity:Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.