BD-PT5112

Fractalkine Receptor Rabbit Polyclonal Antibody

CX3CR1; CMKBRL1; GPR13; CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

常规抗体

CX3CR1

CX3C chemokine receptor 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1524

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1524

P49238

http://www.uniprot.org/uniprotkb/P49238/entry

13051

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13051

Q9Z0D9

http://www.uniprot.org/uniprot/Q9Z0D9

171056

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171056

P35411

http://www.uniprot.org/uniprot/P35411

Synthesized peptide derived from Fractalkine Receptor . at AA range: 120-200

Fractalkine Receptor Polyclonal Antibody detects endogenous levels of Fractalkine Receptor protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200

40kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],

Expressed in lymphoid and neural tissues (PubMed:7590284). Expressed in lymphocyte subsets, such as natural killer (NK) cells, gamma-delta T-cells and terminally differentiated CD8(+) T-cells (PubMed:12055230). Expressed in smooth muscle cells in atherosclerotic plaques (PubMed:14581400).

Cell membrane ; Multi-pass membrane protein .

Cytokine-cytokine receptor interaction;Chemokine;

function:Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.,polymorphism:Variations in CX3CR1 are associated with rapid progression to AIDS [MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.,tissue specificity:Expressed in lymphoid and neural tissues.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.