产品名称
K-cadherin Rabbit Polyclonal Antibody
别名
CDH6; Cadherin-6; Kidney cadherin; K-cadherin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1004
Human Swissprot No.
P55285
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55285/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12563
Mouse Swissprot No.
P97326
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97326
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25409
Rat Swissprot Link
http://www.uniprot.org/uniprot/P55280
免疫原
Synthesized peptide derived from K-cadherin . at AA range: 180-260
特异性
K-cadherin Polyclonal Antibody detects endogenous levels of K-cadherin protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011],
组织表达
Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
细胞定位
Cell membrane; Single-pass type I membrane protein.
功能
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
