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Actin-α cardiac muscle Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5110
产品名称
Actin-α cardiac muscle Rabbit Polyclonal Antibody
别名
ACTC1; ACTC; Actin, alpha cardiac muscle 1; Alpha-cardiac actin
类别
常规抗体
基因名称
ACTC1
蛋白名称
Actin alpha cardiac muscle 1
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
70
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70
Human Swissprot No.
P68032
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P68032/entry
Mouse Gene ID
11464
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11464
Mouse Swissprot No.
P68033
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P68033
Rat Gene ID
29275
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29275
Rat Swissprot No.
P68035
Rat Swissprot Link
http://www.uniprot.org/uniprot/P68035
免疫原
Synthesized peptide derived from Actin-α cardiac muscle . at AA range: 1-80
特异性
Actin-α cardiac muscle Polyclonal Antibody detects endogenous levels of Actin-α cardiac muscle protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
42kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008],
组织表达
Muscle,Tongue,
细胞定位
Cytoplasm, cytoskeleton.
信号通路
Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;
功能
disease:Defects in ACTC1 are the cause of cardiomyopathy dilated type 1R (CMD1R) [MIM:102540]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in ACTC1 are the cause of cardiomyopathy familial hypertrophic type 11 (CMH11) [MIM:612098]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of mouse heart, mouse lung cells using Actin-α cardiac muscle Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded rat-muscle, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded rat-muscle, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-muscle, antibody was diluted at 1:100

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