产品名称
NRAM2 Rabbit Polyclonal Antibody
别名
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1)
基因名称
SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.156% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4891
Human Swissprot No.
P49281
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49281/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18174
Mouse Swissprot No.
P49282
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P49282
Rat Gene Link
https://www.uniprot.org/uniprot/25715
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54902
免疫原
Synthesized peptide derived from human NRAM2 AA range: 474-524
特异性
This antibody detects endogenous levels of NRAM2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010],
组织表达
Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.
细胞定位
[Isoform 2]: Cell membrane ; Multi-pass membrane protein . Early endosome .; Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Also found in extracellular vesicles different from exosomes. .
功能
disease:Defects in SLC11A2 are a cause of hypochromic microcytic anemia [MIM:206100]. The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels.,function:Macrophage-specific membrane transport. Important in metal transport, in particular iron.,similarity:Belongs to the NRAMP family.,tissue specificity:Expressed at low levels in all tissues analyzed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
