产品名称
LIF Rabbit Polyclonal Antibody
别名
LIF; HILDA; Leukemia inhibitory factor; LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin
蛋白名称
Leukemia inhibitory factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3976
Human Swissprot No.
P15018
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P15018/entry
Mouse Swissprot No.
P09056
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09056
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human LIF. AA range:141-190
特异性
LIF Polyclonal Antibody detects endogenous levels of LIF protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
leukemia inhibitory factor(LIF) Homo sapiens The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
function:LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.,online information:Leukemia inhibitory factor entry,pharmaceutical:In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).,similarity:Belongs to the LIF/OSM family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
