产品名称
SLC6A14 Rabbit Polyclonal Antibody
别名
SLC6A14; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+; Amino acid transporter ATB0+; Solute carrier family 6 member 14
蛋白名称
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11254
Human Swissprot No.
Q9UN76
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UN76/entry
Mouse Swissprot No.
Q9JMA9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JMA9
免疫原
Synthesized peptide derived from the C-terminal region of human SLC6A14.
特异性
SLC6A14 Polyclonal Antibody detects endogenous levels of SLC6A14 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010],
组织表达
Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.
细胞定位
Membrane; Multi-pass membrane protein.
功能
disease:Genetic variations in SLC6A14 may be associated with susceptibility to X-linked obesity (OBX) [MIM:300306]. Obesity has been shown to predispose to disorders such as type 2 diabetes, coronary heart disease, hypertension, osteoarthritis, and certain cancers. Common forms of obesity are most likely caused by multiple genetic and environmental factors, and their interactions.,function:Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.,miscellaneous:Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
