产品名称
ATP1AL1 Rabbit Polyclonal Antibody
别名
ATP12A; ATP1AL1; Potassium-transporting ATPase alpha chain 2; Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump
蛋白名称
Potassium-transporting ATPase alpha chain 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=479
Human Swissprot No.
P54707
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54707/entry
Mouse Swissprot No.
Q9Z1W8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1W8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P54708
免疫原
Synthesized peptide derived from ATP1AL1 . at AA range: 380-460
特异性
ATP1AL1 Polyclonal Antibody detects endogenous levels of ATP1AL1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
组织表达
Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
信号通路
Oxidative phosphorylation;
功能
catalytic activity:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).,function:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of two subunits: alpha (catalytic) and beta.,tissue specificity:Found in skin and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
