产品名称
TRPV3 Rabbit Polyclonal Antibody
别名
TRPV3; Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3
蛋白名称
Transient receptor potential cation channel subfamily V member 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=162514
Human Swissprot No.
Q8NET8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NET8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246788
Mouse Swissprot No.
Q8K424
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K424
免疫原
Synthesized peptide derived from the Internal region of human TRPV3.
特异性
TRPV3 Polyclonal Antibody detects endogenous levels of TRPV3 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
transient receptor potential cation channel subfamily V member 3(TRPV3) Homo sapiens This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
组织表达
Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
细胞定位
Membrane; Multi-pass membrane protein.
功能
function:Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subunit:May form a heteromeric channel with TRPV1. Interacts with TRPV1.,tissue specificity:Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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