产品名称
SGPL1 Rabbit Polyclonal Antibody
别名
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.158% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8879
Human Swissprot No.
O95470
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95470/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20397
Mouse Swissprot No.
Q8R0X7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0X7
Rat Gene Link
https://www.uniprot.org/uniprot/286896
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHN6
免疫原
Synthesized peptide derived from human SGPL1 AA range: 393-443
特异性
This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).
细胞定位
Endoplasmic reticulum membrane ; Single-pass type III membrane protein ; Cytoplasmic side .
功能
catalytic activity:Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.,cofactor:Pyridoxal phosphate.,function:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.,tissue specificity:Found in liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
