产品名称
IL-28Rα Rabbit Polyclonal Antibody
别名
IL28RA; IFNLR1; LICR2; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12;CRF2-12; Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Likely interleukin or cytokine receptor 2; LICR2
蛋白名称
Interleukin-28 receptor subunit alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=163702
Human Swissprot No.
Q8IU57
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IU57/entry
Mouse Swissprot No.
Q8CGK5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGK5
免疫原
Synthesized peptide derived from the Internal region of human IL-28Rα.
特异性
IL-28Rα Polyclonal Antibody detects endogenous levels of IL-28Rα protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
细胞定位
Membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
function:The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 1 fibronectin type-III domain.,subunit:Heterodimer with IL10RB.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
