产品名称
SS-56 Rabbit Polyclonal Antibody
别名
TRIM68; GC109; RNF137; SS56; E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68
蛋白名称
E3 ubiquitin-protein ligase TRIM68
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55128
Human Swissprot No.
Q6AZZ1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6AZZ1/entry
Mouse Swissprot No.
Q8K243
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K243
免疫原
Synthesized peptide derived from the Internal region of human SS-56.
特异性
SS-56 Polyclonal Antibody detects endogenous levels of SS-56 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
细胞定位
Cytoplasm, perinuclear region. Nucleus. Colocalized with AR in nucleus.
功能
disease:Target of immune response in patients with systemic lupus erythematosus (SLE), primary Sjoegren syndrome or HIV-1 infection.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,tissue specificity:Detected in all tissues. High expression is noted in spleen and in fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
