产品名称
UBE2A/B Rabbit Polyclonal Antibody
别名
UBE2A; RAD6A; Ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; UBE2B; RAD6B; Ubiquitin-conjugating enzyme E2 B;RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B
蛋白名称
Ubiquitin-conjugating enzyme E2 A/Ubiquitin-conjugating enzyme E2 B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7320
Human Swissprot No.
P49459/P63146
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49459/P63146/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22209/22210
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81816
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63149
免疫原
Synthesized peptide derived from the C-terminal region of human UBE2A/B.
特异性
UBE2A/B Polyclonal Antibody detects endogenous levels of UBE2A/B protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
Lung,Skin,Subthalamic nucleus,Thyroid,
细胞定位
chromatin,nuclear chromatin,XY body,cytoplasm,cytosol,HULC complex,
信号通路
Ubiquitin mediated proteolysis;
功能
catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with RAD18.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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