产品名称
Nup88 Rabbit Polyclonal Antibody
别名
NUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
蛋白名称
Nuclear pore complex protein Nup88
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4927
Human Swissprot No.
Q99567
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99567/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19069
Mouse Swissprot No.
Q8CEC0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CEC0
免疫原
Synthesized peptide derived from Nup88 . at AA range: 330-410
特异性
Nup88 Polyclonal Antibody detects endogenous levels of Nup88 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
细胞定位
Nucleus, nuclear pore complex .
功能
function:Essential component of nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Interacts with NUP214/CAN.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
