产品名称
GABAA Rε Rabbit Polyclonal Antibody
别名
GABRE; Gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon
蛋白名称
Gamma-aminobutyric acid receptor subunit epsilon
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2564
Human Swissprot No.
P78334
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P78334/entry
免疫原
Synthesized peptide derived from the Internal region of human GABAA range: Rε.
特异性
GABAA Rε Polyclonal Antibody detects endogenous levels of GABAA Rε protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008],
组织表达
Expressed in many tissues. Highest levels of expression in adult heart and placenta.
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. Associates with alpha and beta subunits.,tissue specificity:Expressed in many tissues. Highest levels of expression in adult heart and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
