BD-PT5060

ABCG1 Rabbit Polyclonal Antibody

ABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog

常规抗体

ABCG1

ATP-binding cassette sub-family G member 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

9619

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9619

P45844

http://www.uniprot.org/uniprotkb/P45844/entry

11307

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11307

Q64343

http://www.uniprot.org/uniprot/Q64343

Synthesized peptide derived from ABCG1 . at AA range: 560-640

ABCG1 Polyclonal Antibody detects endogenous levels of ABCG1 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:10000.. IF 1:50-200

75kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008],

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell membrane . Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

ABC transporters;

alternative products:Additional isoforms seem to exist,disease:Overexpressed in macrophages from patients with Tangier disease compared to control macrophages. Expressed in foamy macrophages within the atherosclerotic plaque. May play a role in the cholesterol metabolism of macrophages in vitro and in the atherosclerotic plaque.,function:Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.,induction:Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.,similarity:Belongs to the ABC transporter family. ABCG (White) subfamily.,similarity:Contains 1 ABC transmembrane type-2 domain.,similarity:Contains 1 ABC transporter domain.,subcellular location:Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.,subunit:May form heterodimers with several heterologous partners of the ABCG subfamily.,tissue specificity:Expressed in several tissues.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.