产品名称
FHR5 Rabbit Polyclonal Antibody
别名
Complement factor H-related protein 5 (FHR-5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81494
Human Swissprot No.
Q9BXR6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BXR6/entry
免疫原
Synthesized peptide derived from human FHR5 AA range: 353-403
特异性
This antibody detects endogenous levels of FHR5 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010],
组织表达
Expressed by the liver and secreted in plasma.
功能
function:Involved in complement regulation.,similarity:Contains 9 Sushi (CCP/SCR) domains.,subunit:Binds C3b in vitro.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
