产品名称
PDE6D Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5147
Human Swissprot No.
O43924
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43924/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18582
Mouse Swissprot No.
O55057
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55057
免疫原
Synthesized peptide derived from human PDE6D AA range: 89-139
特异性
This antibody detects endogenous levels of PDE6D at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014],
组织表达
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
细胞定位
Cytoplasm, cytosol . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, cilium basal body .
功能
similarity:Belongs to the PDE6D/unc-119 family.,subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. Interacts with RPGR, ARL2 and ARL3.,tissue specificity:Retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
